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WELCOME TO YONEHARA LAB

DANDRITENordic EMBLAarhus University

We seek to address the following questions:

  • How are sensory inputs processed by central circuits?
  • What is the function of individual cell types in computation and behaviour?
  • What are the genetic and activity-dependent mechanisms of circuit development?

We address these questions mainly by focusing on visual circuits across retina, superior colliculus, thalamus and visual cortex. The logic of our research plan is to first identify a computation performed by a given neuronal circuit comprising distinct cell types in the adult brain. Second, to investigate how the computation is performed by linking the activity and synaptic connectivity of individual cell types in the circuit to the computation that the circuit achieves. Third, to examine the role of individual cell types in transforming the sensory input into output behavior. Finally, to study the genetic mechanisms by which the elementary circuit motifs are assembled, and how its dysfunction can lead to disease.

We perform cell-type-specific experiments that require a wide spectrum of experimental approaches from molecular biology, genomics, genetics, electrophysiology, optogenetics, multi-photon functional imaging, trans-synaptic viral tracing, and behavioral analysis. We are developing new genetic and viral technologies that facilitate probing circuit function in healthy and diseased systems.

Youtube video abstract: Horizontal Direction Selectivity Depends on Congenital Nystagmus Gene FRMD7SPACE

 

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Genes – Cell types – Circuits – Behaviour